Substance Identity
CAS Number 96-29-7
Chemical Name 2-Butanone, oxime
Type of substance Organic
SMILES N(O)=C(CC)C
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? Yes
Meets Environmental Criteria for Categorization? No
Persistent (P)? Yes
Rational for P QSAR
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? No
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1000T

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Air-Water
Experimental Biodegradation half-life (days) Not Available
Robust Study Summary (biodegradation result)
96297.doc
Predicted Ultimate degradation half-life (days) 15
MITI probability of biodegradation 0.6175
TOPKAT probability of biodegradation 0
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 7.211

Underlying data regarding Bioaccumulation

Empirical Log Kow 0.63
Reference (Log Kow) EPISUITE KOWWIN v1.67
Log Kow predicted by KowWin 1.69
Log BAF T2MTL predicted by Gobas 0.0767479096231847
Log BCF 5% T2LTL predicted by Gobas 0.062721191238884
Log BCF Max predicted by OASIS 1.53237234091603
Log BCF predicted by BCFWIN 0.5
Experimental BCF (log) 0.179059945366348
Reason for pivotal value Average Vertebrate BCF
Test species BCF/BAF (Latin) Cyprinus carpio
Test species BCF/BAF (Common) Common carp
Mean water concentration (ug/l) 2,000
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (days) 42
Exposure duration (comment) Sufficient exposure duration for 80% steady state; "Reported steady state"
Exposure type Flow-through
Mean temperature (deg. Celcius) 22
Exposure route Water (but fed)
Exposure media Fresh Water
Mean measured lipid content (%) 4.9
Tissue analysed Whole body
Calculation method Cb/Cw
Comment (BAF/BCF) Average BCF; Apparent measured water concentrations; Reported "Steady state"
Reference (BAF/BCF) Chemicals Evaluation and Research Institute. 1992. Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. http://qsar.cerij.or.jp/cgi-bin/DEGACC/index.cgi?e

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 843
Experimental result iT (mg/l) 843
Test species iT (Latin) Pimephales promelas
Test species iT (Common) Fathead minnow
Final EndPoint iT LC50
Exposure duration iT (hours) 96
Reference iT Center for Lake Superior Environmental Stud., Univ.of Wisconsin-Superior, Superior, WI :414
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 37.89
Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10 292.9831
Toxicity to fish (LC50 in mg/l) as predicted by Aster 1,197.594875
Toxicity to fish (LC50 in mg/l) as predicted by PNN 1,510.16505
Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1 1,600
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 2.686
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 1.26E+000

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Greatest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment

AgencyAssessment
EC Carcinogenicity - Category 3

Underlying data regarding Complex Hazard Assessment