Substance Identity
CAS Number 60-00-4
Chemical Name Glycine, N,N -1,2-ethanediylbis[N-(carboxymethyl)-
Type of substance Organic
SMILES O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? Yes
Meets Environmental Criteria for Categorization? No
Persistent (P)? Yes
Rational for P Experiment
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? No
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1000T

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Water
Experimental Biodegradation half-life (days) Not Available
Experimental Biodegradation result (%) 3
Reference (biodegradation result) Gerike, P. & Fischer, W.K. 1979. A correlation study of biodegradability determinations with various chemicals in various tests. Ecotoxicology and Environmental Safety 3: 159 – 173.
Robust Study Summary (biodegradation result)
60004.doc
Predicted Ultimate degradation half-life (days) 8.67
MITI probability of biodegradation 0.3834
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 0.05893

Underlying data regarding Bioaccumulation

Log Kow predicted by KowWin -3.86
Log BAF T2MTL predicted by Gobas 0.0000540371955876
Log BCF 5% T2LTL predicted by Gobas 0.0005144646215092
Log BCF Max predicted by OASIS 0.931554395276083
Log BCF predicted by BCFWIN 0.5
Experimental BCF (log) 0.10096878997735
Reason for pivotal value Average Vertebrate BCF (Radiolabel used; conservative estimate)
Test species BCF/BAF (Latin) Lepomis macrochirus
Test species BCF/BAF (Common) Bluegill sunfish
Mean water concentration (ug/l) 760
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel Yes, total
Exposure duration (days) 5
Exposure duration (comment) Sufficient exposure duration for 80% steady state; K1/K2
Exposure type Flow-through
Mean temperature (deg. Celcius) 21
Exposure route Water (but fed)
Exposure media Fresh Water
Tissue analysed Whole body
Calculation method BIOFAC
Comment (BAF/BCF) BIOFAC
Reference (BAF/BCF) Bishop, W.E., and A.W. Maki. 1980. A Critical Comparison of Two Bioconcentration Test Methods. In: J.G.Eaton, P.R.Parrish, and A.C.Hendricks (Eds.), Aquatic Toxicology, ASTM STP 707: :61-77

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 59.8
Experimental result iT (mg/l) 59.8
Test species iT (Latin) Pimephales promelas
Test species iT (Common) Fathead minnow
Final EndPoint iT LC50
Exposure duration iT (hours) 96
Reference iT J.Hydrol.51:359-367 (Author Communication Used)
Robust Study Summary iT
60004-AT-LC50-F-pimpro.doc
60004-AT-LC50-I-anoimb.doc
Toxicity to fish (LC50 in mg/l) as predicted by PNN 74.94281
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 39,173.363
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 6.98E+005

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Greatest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment


Underlying data regarding Complex Hazard Assessment