Substance Identity
CAS Number 25265-71-8
Chemical Name Propanol, oxybis-
Type of substance Organic
SMILES CC(O)COCC(O)C
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? No
Meets Human Health Categorization Criteria? No
Meets Environmental Criteria for Categorization? No
Persistent (P)? No
Rational for P Category
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? No
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1000T

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Water
Experimental Biodegradation half-life (days) Not Available
Experimental Biodegradation result (%) 88.4
Reference (biodegradation result) IUCLID Data Set, ACC Propylene Oxide/Propylene Glycol Panel, May 23, 2001
Robust Study Summary (biodegradation result)
25265718.doc
Predicted Ultimate degradation half-life (days) 15
MITI probability of biodegradation 0.7776
TOPKAT probability of biodegradation 0.889
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 0.3414

Underlying data regarding Bioaccumulation

Log Kow predicted by KowWin -0.64
Log BAF T2MTL predicted by Gobas 0.0000540371955876
Log BCF 5% T2LTL predicted by Gobas 0.0005144646215092
Log BCF Max predicted by OASIS 0.990947722309349
Log BCF predicted by BCFWIN 0.5
Experimental BCF (log) 0.230972662943506
Reason for pivotal value Average Vertebrate BCF
Test species BCF/BAF (Latin) Cyprinus carpio
Test species BCF/BAF (Common) Common carp
Mean water concentration (ug/l) 3,000
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (days) 42
Exposure duration (comment) Sufficient exposure duration for 80% steady state; "Reported steady state"
Exposure type Flow-through
Mean temperature (deg. Celcius) 22
Exposure route Water (but fed)
Exposure media Fresh Water
Mean measured lipid content (%) 3.8
Tissue analysed Whole body
Calculation method Cb/Cw
Comment (BAF/BCF) Average BCF; Apparent measured water concentrations; Reported "Steady state"
Reference (BAF/BCF) Chemicals Evaluation and Research Institute. 1992. Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. http://qsar.cerij.or.jp/cgi-bin/DEGACC/index.cgi?e

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 5000
Experimental result iT (mg/l) 5000
Test species iT (Latin) Carassius auratus
Test species iT (Common) Goldfish
Final EndPoint iT LC50
Exposure duration iT (hours) 24
Reference iT Water Res. 13(7):623-626 (OECDG Data File)
Robust Study Summary iT
25265718_AT_LC50_pimpro.doc
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 30,149.313
Toxicity to fish (LC50 in mg/l) as predicted by Aster 33,363.402
Toxicity to fish (LC50 in mg/l) as predicted by PNN 6,557.3547
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 14,456.974
Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g 434.988
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 3.02E+004

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Greatest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment


Underlying data regarding Complex Hazard Assessment

Carcinogencity

Screening Outcome Negative
Screening Method
Data Results
Reference Hooth, 2004, Toxycology 204:123-140

Genotoxicity

Screening Outcome Negative
Screening Method
Data Results in vivo Mammalian Germ Cell Clastogen or Aneugen
Reference Dow Chemical Company, 1999, unpublished (as cited in SIDS 2001) National Cancer Institute, unpublished, project Y86 (as cited in CCRIS, 2001)+J403

Developmental Toxicity

Screening Outcome Negative
Screening Method
Data Results NO(A)EL 1200 mg/kg bw
Reference NTP, 1992, TER90014