Substance Identity
CAS Number 90-94-8
Chemical Name Methanone, bis[4-(dimethylamino)phenyl]-
Type of substance Organic
SMILES O=C(c(ccc(N(C)C)c1)c1)c(ccc(N(C)C)c2)c2
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? Yes
Meets Environmental Criteria for Categorization? No
Persistent (P)? Yes
Rational for P QSAR
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? No
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1T to 1000T

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Water
Experimental Biodegradation half-life (days) Not Available
Robust Study Summary (biodegradation result)
90948.doc
Predicted Ultimate degradation half-life (days) 60
MITI probability of biodegradation 0.0065
TOPKAT probability of biodegradation 0
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 0.05216

Underlying data regarding Bioaccumulation

Empirical Log Kow 3.87
Reference (Log Kow) CLOGP (1986)
Log Kow predicted by KowWin 3.5
Log BAF T2MTL predicted by Gobas 1.00056624289802
Log BCF 5% T2LTL predicted by Gobas 0.999124135150924
Log BCF Max predicted by OASIS 2.84749105895824
Log BCF predicted by BCFWIN 1.44
Experimental BCF (log) 1.52094905898494
Reason for pivotal value Average Vertebrate BCF
Test species BCF/BAF (Latin) Cyprinus carpio
Test species BCF/BAF (Common) Common carp
Mean water concentration (ug/l) 20
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (days) 56
Exposure duration (comment) Sufficient exposure duration for 80% steady state; "Reported steady state"
Exposure type Flow-through
Mean temperature (deg. Celcius) 22
Exposure route Water (but fed)
Exposure media Fresh Water
Mean measured lipid content (%) 4.3
Tissue analysed Whole body
Calculation method Cb/Cw
Comment (BAF/BCF) Average BCF; Apparent measured water concentrations; Reported "Steady state"
Reference (BAF/BCF) Chemicals Evaluation and Research Institute. 1992. Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. http://qsar.cerij.or.jp/cgi-bin/DEGACC/index.cgi?e

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 100
Experimental result iT (mg/l) 100
Test species iT (Latin) Daphnia mag
Test species iT (Common) Water flea
Final EndPoint iT EC50
Exposure duration iT (hours) 48
Reference iT 52CVDS
Robust Study Summary iT
90-94-8_52CVDS.doc
Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1 0.8886
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 7.74
Toxicity to fish (LC50 in mg/l) as predicted by Aster 4.415533
Toxicity to fish (LC50 in mg/l) as predicted by PNN 173.59947
Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1 3.8
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 0.765
Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g 0.909
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 7.74E+000

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Intermediate Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment

AgencyAssessment
EC Genotoxicity - Category 3
NTP Carcinogenicity - Reasonably anticipated to be a human carcinogen
EC Carcinogenicity - Category 2

Underlying data regarding Complex Hazard Assessment