Substance Identity
CAS Number 120-82-1
Chemical Name Benzene, 1,2,4-trichloro-
Type of substance Organic
SMILES c(ccc(c1Cl)Cl)(c1)Cl
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? No
Meets Environmental Criteria for Categorization? Yes
Persistent (P)? Yes
Rational for P Experiment
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? Yes
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1T to 1000T
Basis for Environment Categorization (PiT, BiT, PBiT) if categorized? PiT

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Air-Soil
Experimental Biodegradation half-life (days) Not Available
Experimental Biodegradation result (%) 0
Reference (biodegradation result) CHEMICALS INSPECTION AND TESTING INSTITUTE.; BIODEGRADATION AND BIOACCUMULATION DATA OF EXISTING CHEMICALS BASED ON THE CSCL JAPAN.; JAPAN CHEMICAL INDUSTRY ECOLOGY - TOXICOLOGY AND INFORMATION CENTER.ISBN 4-89074-101-1.; 1992
Robust Study Summary (biodegradation result)
MITI book - P data.doc
Predicted Ultimate degradation half-life (days) 60
MITI probability of biodegradation 0.047
TOPKAT probability of biodegradation 0.002
EPI Predicted Ozone reaction half-life (days) 999
Experimental Atmospheric Oxidation half-life (days) 19.4444444444444
Reference (oxidation) ATKINSON,R.; KINETICS AND MECHANISMS OF THE GAS-PHASE REACTIONS OF THE HYDROXYL RADICAL WITH ORGANIC COMPOUNDS.; JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA. MONOGRAPH NO. 1.; 1989
EPI Predicted Atmospheric Oxidation half-life (days) 37.97

Underlying data regarding Bioaccumulation

Empirical Log Kow 4.02
Reference (Log Kow) HANSCH,C & LEO,AJ (1985)
Log Kow predicted by KowWin 3.93
Log BAF T2MTL predicted by Gobas 2.32093610082762
Log BCF 5% T2LTL predicted by Gobas 2.28575275526149
Log BCF Max predicted by OASIS 3.25357472149441
Log BCF predicted by BCFWIN 2.395
Experimental BAF (log) 3.52
Experimental BCF (log) 3.37533180025875
Reason for pivotal value Highest Vertebrate BAF
Test species BCF/BAF (Latin) Brevoortia patronus
Test species BCF/BAF (Common) Gulf menhaden
Mean water concentration (ug/l) 0.268
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (comment) Lifetime exposure; assumed steady state
Exposure type Lotic
Mean temperature (deg. Celcius) N/A
Exposure route Water & Diet
Exposure media Brackish/Fresh Water Marsh
Tissue analysed Whole body
Calculation method Cb/Cw
Comment (BAF/BCF) Lipid based BAF
Reference (BAF/BCF) Burkhard, L.P., et al. 1997. Bioaccumulation Factors for Chlorinated Benzenes, Chlorinated Butadienes and Hexachloroethane. Environmental Toxicology and Chemistry 16(8):1677-1686

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 0.09
Experimental result iT (mg/l) 0.09
Test species iT (Latin) Crangon septemspinosa
Test species iT (Common) Bay shrimp, Sand shrimp
Final EndPoint iT LC50
Exposure duration iT (hours) 96
Reference iT Rep.No.4398, Fil Report, EPA Contract No.68-01-6201, NUS Corp., Houston, Tx :196
Robust Study Summary iT
120821-AT-EC50-O-scesub.doc
120821-AT-LC50-I-crasep.doc
Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1 3.1
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 2.063
Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10 2.0647
Toxicity to fish (LC50 in mg/l) as predicted by Aster 2.384199
Toxicity to fish (LC50 in mg/l) as predicted by PNN 1.96534
Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1 1.9
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 0.15
Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g 0.301
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 2.06E+000

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Lowest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment


Underlying data regarding Complex Hazard Assessment