Substance Identity
CAS Number 533-74-4
Chemical Name 2H-1,3,5-Thiadiazine-2-thione, tetrahydro-3,5-dimethyl-
Type of substance Organic
SMILES N(CSC(N1C)=S)(C1)C
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? No
Meets Human Health Categorization Criteria? No
Meets Environmental Criteria for Categorization? No
Persistent (P)? No
Rational for P QSAR
Bioaccumulative (B)? No
Rational for B QSAR
Inherently Toxic to Aquatic Organisms (iT)? Yes
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1T to 1000T

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Water
Experimental Biodegradation half-life (days) Not Available
Robust Study Summary (biodegradation result)
533744.doc
Predicted Ultimate degradation half-life (days) 37.5
MITI probability of biodegradation 0.1123
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 0.03756

Underlying data regarding Bioaccumulation

Empirical Log Kow 1.4
Log Kow predicted by KowWin 0.94
Log BAF T2MTL predicted by Gobas 0.401978212815453
Log BCF 5% T2LTL predicted by Gobas 0.348300164442709
Log BCF Max predicted by OASIS 1.24561063375947
Log BCF predicted by BCFWIN 0.378

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 0.038
Experimental result iT (mg/l) 0.038
Test species iT (Latin) Skeletonema costatum
Test species iT (Common) Diatom
Final EndPoint iT EC50
Exposure duration iT (hours) 120
Reference iT Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.
Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1 1,200
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 213.125
Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10 2,267.5066
Toxicity to fish (LC50 in mg/l) as predicted by Aster 887.14775
Toxicity to fish (LC50 in mg/l) as predicted by PNN 4,910.0259
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 13.718
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 1.19E+001

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Intermediate Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment


Underlying data regarding Complex Hazard Assessment