Substance Identity
CAS Number 108-70-3
Chemical Name Benzene, 1,3,5-trichloro-
Type of substance Organic
SMILES c(cc(cc1Cl)Cl)(c1)Cl
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? No
Meets Environmental Criteria for Categorization? Yes
Persistent (P)? Yes
Rational for P Experiment
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? Yes
Rational for iT Experiment
DSL Quantity range (tonnes/year) 0 to 1T
Basis for Environment Categorization (PiT, BiT, PBiT) if categorized? PiT

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Air-Soil
Experimental Biodegradation half-life (days) Not Available
Experimental Biodegradation result (%) 0
Reference (biodegradation result) CHEMICALS INSPECTION AND TESTING INSTITUTE.; BIODEGRADATION AND BIOACCUMULATION DATA OF EXISTING CHEMICALS BASED ON THE CSCL JAPAN.; JAPAN CHEMICAL INDUSTRY ECOLOGY - TOXICOLOGY AND INFORMATION CENTER.ISBN 4-89074-101-1.; 1992
Robust Study Summary (biodegradation result)
108703.doc
MITI book - P data.doc
Predicted Ultimate degradation half-life (days) 60
MITI probability of biodegradation 0.047
TOPKAT probability of biodegradation 0.096
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 15.76

Underlying data regarding Bioaccumulation

Empirical Log Kow 4.19
Reference (Log Kow) HANSCH,C & LEO,AJ (1985)
Log Kow predicted by KowWin 3.93
Log BAF T2MTL predicted by Gobas 3.10197149033974
Log BCF 5% T2LTL predicted by Gobas 2.89343883190288
Log BCF Max predicted by OASIS 3.25357472149441
Log BCF predicted by BCFWIN 2.526
Experimental BAF (log) 2.74
Experimental BCF (log) 3.49007384479515
Reason for pivotal value Highest Vertebrate BAF
Test species BCF/BAF (Latin) Micropogonias undulatus
Test species BCF/BAF (Common) Atlantic croaker
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (comment) Lifetime exposure; assumed steady state
Exposure type Lotic
Mean temperature (deg. Celcius) N/A
Exposure route Water & Diet
Exposure media Brackish/Fresh Water Marsh
Mean measured lipid content (%) 2.2
Tissue analysed Whole body
Calculation method Cb/Cw
Comment (BAF/BCF) Lipid based BAF; Calcasieu River estuary; Migratory animals: Chemical conc. Near industrial outfall; Kow salinity corrected
Reference (BAF/BCF) Pereira, W.E. et al.. 1988. Contamination of Estuarine Water, Biota and Sediment by Halogenated Organic Compounds: A Field Study. Environ. Sci Technol. 22:772-778

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 0.59
Experimental result iT (mg/l) 0.59
Test species iT (Latin) Cyclotella meneghinia
Test species iT (Common) Diatom
Final EndPoint iT EC50
Exposure duration iT (hours) 48
Reference iT Ph.D.Thesis, University of Michigan, Ann Arbor, MI:232 p.; Diss.Abstr.Int.B Sci.Eng.51(4):1722-B
Robust Study Summary iT
108703-AT-EC50-O-cycmen.doc
Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1 7,800
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 2.063
Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10 2.1227
Toxicity to fish (LC50 in mg/l) as predicted by Aster 2.11061
Toxicity to fish (LC50 in mg/l) as predicted by PNN 1.96534
Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1 2.9
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 0.15
Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g 0.301
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 2.06E+000

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Lowest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment


Underlying data regarding Complex Hazard Assessment