Canadian Categorization Results

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Substance Identity

CAS Number	3296-90-0
Chemical Name	1,3-Propanediol, 2,2-bis(bromomethyl)-
Type of substance	Organic
SMILES	OCC(CBr)(CBr)CO
Moiety of concern	organic

Categorization Results

Meets Government of Canada Categorization Criteria?	Yes
Meets Human Health Categorization Criteria?	Yes
Meets Environmental Criteria for Categorization?	No
Persistent (P)?	Yes
Rational for P	Experiment
Bioaccumulative (B)?	No
Rational for B	Experiment
Inherently Toxic to Aquatic Organisms (iT)?	No
Rational for iT	Experiment
DSL Quantity range (tonnes/year)	>1T to 1000T

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization

Water

Experimental Biodegradation half-life (days)

Not Available

Experimental Biodegradation result (%)

Reference (biodegradation result)

CHEMICALS INSPECTION AND TESTING INSTITUTE.; BIODEGRADATION AND BIOACCUMULATION DATA OF EXISTING CHEMICALS BASED ON THE CSCL JAPAN.; JAPAN CHEMICAL INDUSTRY ECOLOGY - TOXICOLOGY AND INFORMATION CENTER.ISBN 4-89074-101-1.; 1992

Robust Study Summary (biodegradation result)

MITI book - P data.doc

Predicted Ultimate degradation half-life (days)

MITI probability of biodegradation

0.1168

TOPKAT probability of biodegradation

EPI Predicted Ozone reaction half-life (days)

999

EPI Predicted Atmospheric Oxidation half-life (days)

1.193

Underlying data regarding Bioaccumulation

Empirical Log Kow	1.06
Reference (Log Kow)	HANSCH,C & LEO,AJ (1985)
Log Kow predicted by KowWin	0.85
Log BAF T2MTL predicted by Gobas	0.22060821139312
Log BCF 5% T2LTL predicted by Gobas	0.18597381714812
Log BCF Max predicted by OASIS	1.22120179463271
Log BCF predicted by BCFWIN	0.116
Experimental BCF (log)	0.327808537529434
Reason for pivotal value	Average Vertebrate BCF
Test species BCF/BAF (Latin)	Cyprinus carpio
Test species BCF/BAF (Common)	Common carp
Mean water concentration (ug/l)	3,000
Mean water concentration (comment)	Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain	Measured
RadioLabel	No
Exposure duration (days)	42
Exposure duration (comment)	Sufficient exposure duration for 80% steady state; "Reported steady state"
Exposure type	Flow-through
Mean temperature (deg. Celcius)	22
Exposure route	Water (but fed)
Exposure media	Fresh Water
Mean measured lipid content (%)	4.6
Tissue analysed	Whole body
Calculation method	Cb/Cw
Comment (BAF/BCF)	Average BCF; Apparent measured water concentrations; Reported "Steady state"
Reference (BAF/BCF)	Chemicals Evaluation and Research Institute. 1992. Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. http://qsar.cerij.or.jp/cgi-bin/DEGACC/index.cgi?e

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l)

500

Experimental result iT (mg/l)

500

Test species iT (Latin)

Oryzias latipes

Test species iT (Common)

orange-red killifish

Final EndPoint iT

LC50

Reference iT

Robust Study Summary iT

RSS - MITI book.doc

Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g

2,339.945

Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10

6,837.874

Toxicity to fish (LC50 in mg/l) as predicted by PNN

129.72386

Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1

1,700

Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g

1,355.051

Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g

71.813

Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g

2.34E+003

Human Health data supporting decisions

Underlying data regarding potential for exposure

LPE/IPE/GPE

Lowest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment

Agency	Assessment
IARC	Carcinogenicity - Group 2B

Underlying data regarding Complex Hazard Assessment