Substance Identity
CAS Number 106-93-4
Chemical Name Ethane, 1,2-dibromo-
Type of substance Organic
SMILES BrCCBr
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? Yes
Meets Environmental Criteria for Categorization? Yes
Persistent (P)? Yes
Rational for P Experiment
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? Yes
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1000T
Basis for Environment Categorization (PiT, BiT, PBiT) if categorized? PiT

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Air
Experimental Biodegradation half-life (days) Not Available
Predicted Ultimate degradation half-life (days) 15
MITI probability of biodegradation 0.0411
TOPKAT probability of biodegradation 0
EPI Predicted hydrolysis half-life (days) 2.65E+004
EPI Predicted Ozone reaction half-life (days) 999
Experimental Atmospheric Oxidation half-life (days) 42.7777777777778
Reference (oxidation) ATKINSON,R.; KINETICS AND MECHANISMS OF THE GAS-PHASE REACTIONS OF THE HYDROXYL RADICAL WITH ORGANIC COMPOUNDS.; JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA. MONOGRAPH NO. 1.; 1989
EPI Predicted Atmospheric Oxidation half-life (days) 44.46

Underlying data regarding Bioaccumulation

Empirical Log Kow 1.96
Reference (Log Kow) HANSCH,C & LEO,AJ (1985)
Log Kow predicted by KowWin 2.01
Log BAF T2MTL predicted by Gobas 0.141686850464287
Log BCF 5% T2LTL predicted by Gobas 0.142959985818354
Log BCF Max predicted by OASIS 1.69784503692093
Log BCF predicted by BCFWIN 0.809
Experimental BCF (log) 0.671262883733235
Reason for pivotal value Average Vertebrate BCF
Test species BCF/BAF (Latin) Cyprinus carpio
Test species BCF/BAF (Common) Common carp
Mean water concentration (ug/l) 150
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (days) 42
Exposure duration (comment) Sufficient exposure duration for 80% steady state; "Reported steady state"
Exposure type Flow-through
Mean temperature (deg. Celcius) 22
Exposure route Water (but fed)
Exposure media Fresh Water
Tissue analysed Whole body
Calculation method Cb/Cw
Comment (BAF/BCF) Average BCF; Apparent measured water concentrations; Reported "Steady state"
Reference (BAF/BCF) Chemicals Evaluation and Research Institute. 1992. Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. http://qsar.cerij.or.jp/cgi-bin/DEGACC/index.cgi?e

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 0.0133
Experimental result iT (mg/l) 0.0133
Test species iT (Latin) Oryzias latipes
Test species iT (Common) Medaka, high-eyes
Final EndPoint iT NOEC
Exposure duration iT (hours) 2,160
Reference iT Hawkins W.E., W.W. Walker, M.O. James, C.S. Manning, D.H. Barnes, C.S. Heard and R.M. Overstreet. 1998. Carcinogenic effects of 1,2-dibromoethane (ethylene dibromide; EDB) in Japanese medaka (Oryzias latipes) Mutat. Res. 20; 399(2):221-32.
Robust Study Summary iT
106934_CT_NOEC_F_Orylat.doc
106934-AT-LC50-F-Cenund.doc
106934-AT-LC50-Micsal-2.doc
106934-AT-LC50-F-Cypvar.doc
Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1 201.7
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 136.282
Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10 271.6881
Toxicity to fish (LC50 in mg/l) as predicted by Aster 246.396359
Toxicity to fish (LC50 in mg/l) as predicted by PNN 9.46648
Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1 81.7
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 39.025
Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g 7.527
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 1.36E+002

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Intermediate Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment

AgencyAssessment
EC Carcinogenicity - Category 2
NTP Carcinogenicity - Reasonably anticipated to be a human carcinogen
USEPA 2003 Carcinogenicity - Likely to be carcinogenic to humans
USEPA 1986 Carcinogenicity - Groups B1 and B2
IARC Carcinogenicity - Group 2A

Underlying data regarding Complex Hazard Assessment