Substance Identity
CAS Number 302-79-4
Chemical Name Retinoic acid
Type of substance Organic
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? No
Meets Environmental Criteria for Categorization? Yes
Persistent (P)? No
Rational for P QSAR
Bioaccumulative (B)? Yes
Rational for B QSAR
Inherently Toxic to Aquatic Organisms (iT)? Yes
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1T to 1000T
Basis for Environment Categorization (PiT, BiT, PBiT) if categorized? BiT

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Soil
Experimental Biodegradation half-life (days) Not Available
Predicted Ultimate degradation half-life (days) 37.5
MITI probability of biodegradation 0.0257
EPI Predicted Ozone reaction half-life (days) 0.06394
EPI Predicted Atmospheric Oxidation half-life (days) 0.03656

Underlying data regarding Bioaccumulation

Empirical Log Kow 6.3
Log Kow predicted by KowWin 7.85
Log BAF T2MTL predicted by Gobas 6.03146037587664
Log BCF 5% T2LTL predicted by Gobas 4.57455402075921
Log BCF Max predicted by OASIS 4.20503083429786
Log BCF predicted by BCFWIN 1.75

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 0.0056
Experimental result iT (mg/l) 0.0056
Test species iT (Latin) Xenopus laevis
Test species iT (Common) Clawed toad
Final EndPoint iT EC50
Exposure duration iT (hours) 96
Reference iT Environ.Toxicol.Chem. 10:941-948
Robust Study Summary iT
Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10 3.4852
Toxicity to fish (LC50 in mg/l) as predicted by PNN 5.46204
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 0.003
Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g 0.008
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 3.24E-005

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Lowest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment

Underlying data regarding Complex Hazard Assessment