Substance Identity
CAS Number 131-11-3
Chemical Name 1,2-Benzenedicarboxylic acid, dimethyl ester
Type of substance Organic
SMILES O=C(OC)c(c(ccc1)C(=O)OC)c1
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? No
Meets Human Health Categorization Criteria? No
Other Human Health Priorities? Moderate
Meets Environmental Criteria for Categorization? No
Persistent (P)? Yes
Rational for P Category
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? No
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1T to 1000T

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Air-Water
Experimental Biodegradation half-life (days) Not Available
Experimental Biodegradation result (%) 98
Reference (biodegradation result) CHEMICALS INSPECTION AND TESTING INSTITUTE.; BIODEGRADATION AND BIOACCUMULATION DATA OF EXISTING CHEMICALS BASED ON THE CSCL JAPAN.; JAPAN CHEMICAL INDUSTRY ECOLOGY - TOXICOLOGY AND INFORMATION CENTER.ISBN 4-89074-101-1.; 1992
Robust Study Summary (biodegradation result)
MITI book - P data.doc
Predicted Ultimate degradation half-life (days) 15
MITI probability of biodegradation 0.9114
TOPKAT probability of biodegradation 1
EPI Predicted hydrolysis half-life (days) 1.00E+003
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 18.64

Underlying data regarding Bioaccumulation

Empirical Log Kow 1.6
Reference (Log Kow) HANSCH,C & LEO,AJ (1985)
Log Kow predicted by KowWin 1.66
Log BAF T2MTL predicted by Gobas 0.538060161966732
Log BCF 5% T2LTL predicted by Gobas 0.474098101127741
Log BCF Max predicted by OASIS 1.51824184873476
Log BCF predicted by BCFWIN 0.532
Experimental BAF (log) 3.14
Reason for pivotal value Highest Vertebrate BAF
Test species BCF/BAF (Latin) Squalus acanthias
Test species BCF/BAF (Common) Spiny Dogfish
Mean water concentration (ug/l) 0.00054530711646582
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (comment) Lifetime exposure; assumed steady state
Exposure type Lentic
Mean temperature (deg. Celcius) 8
Exposure route Water & Diet
Exposure media Salt Water
Mean measured lipid content (%) 8.3
Tissue analysed Muscle
Calculation method Cb/Cw
Comment (BAF/BCF) False Creek; BAFs based on lipid normalized tissue; Kow corrected for Salinity
Reference (BAF/BCF) Gobas, F.A.P.C., C.E. Mackintosh, G. Webster, M. Ikonomou, T.F. Parkerton and K. Robillard. 2003. Bioaccumulation of Phtalate Esters in Aquatic Food-Webs. The Handbook of Environmental Chemistry Vol. 3 Part Q: 201-225

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 29
Experimental result iT (mg/l) 29
Test species iT (Latin) Cyprinodon variegatus
Test species iT (Common) Sheepshead minnow
Final EndPoint iT LC50
Exposure duration iT (hours) 96
Reference iT Environ.Toxicol.Chem. 14(9):1569-1574
Robust Study Summary iT
131113-ATstatic-LC50-F-cypvar-2.rtf
Toxicity to fathead minnow (LC50 in mg/l) as predicted by Topkat v6.1 157.8
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 44.681
Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10 104.7313
Toxicity to fish (LC50 in mg/l) as predicted by Aster 14.963061
Toxicity to fish (LC50 in mg/l) as predicted by PNN 56.46353
Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1 11.4
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 314.502
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 1.00E+002

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Intermediate Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment


Underlying data regarding Complex Hazard Assessment