Substance Identity
CAS Number 79-46-9
Chemical Name Propane, 2-nitro-
Type of substance Organic
SMILES N(=O)(=O)C(C)C
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? Yes
Meets Environmental Criteria for Categorization? No
Persistent (P)? Yes
Rational for P Experiment
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? No
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1T to 1000T

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Air-Water
Experimental Biodegradation half-life (days) Not Available
Experimental Biodegradation result (%) 8
Reference (biodegradation result) CHEMICALS INSPECTION AND TESTING INSTITUTE.; BIODEGRADATION AND BIOACCUMULATION DATA OF EXISTING CHEMICALS BASED ON THE CSCL JAPAN.; JAPAN CHEMICAL INDUSTRY ECOLOGY - TOXICOLOGY AND INFORMATION CENTER.ISBN 4-89074-101-1.; 1992
Robust Study Summary (biodegradation result)
MITI book - P data.doc
Predicted Ultimate degradation half-life (days) 15
MITI probability of biodegradation 0.4732
TOPKAT probability of biodegradation 0.95
EPI Predicted Ozone reaction half-life (days) 999
Experimental Atmospheric Oxidation half-life (days) 41.1324786324786
Reference (oxidation) ATKINSON,R.; KINETICS AND MECHANISMS OF THE GAS-PHASE REACTIONS OF THE HYDROXYL RADICAL WITH ORGANIC COMPOUNDS.; JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA. MONOGRAPH NO. 1.; 1989
EPI Predicted Atmospheric Oxidation half-life (days) 63.64

Underlying data regarding Bioaccumulation

Empirical Log Kow 0.93
Reference (Log Kow) CLOGP (1986)
Log Kow predicted by KowWin 0.87
Log BAF T2MTL predicted by Gobas 0.168601883347948
Log BCF 5% T2LTL predicted by Gobas 0.140839820045295
Log BCF Max predicted by OASIS 1.22727304421836
Log BCF predicted by BCFWIN 0.5
Experimental BCF (log) 0.458663603792336
Reason for pivotal value Average Vertebrate BCF
Test species BCF/BAF (Latin) Cyprinus carpio
Test species BCF/BAF (Common) Common carp
Mean water concentration (ug/l) 2,000
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel No
Exposure duration (days) 42
Exposure duration (comment) Sufficient exposure duration for 80% steady state; "Reported steady state"
Exposure type Flow-through
Mean temperature (deg. Celcius) 22
Exposure route Water (but fed)
Exposure media Fresh Water
Mean measured lipid content (%) 4.7
Tissue analysed Whole body
Calculation method Cb/Cw
Comment (BAF/BCF) Average BCF; Apparent measured water concentrations; Reported "Steady state"
Reference (BAF/BCF) Chemicals Evaluation and Research Institute. 1992. Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. http://qsar.cerij.or.jp/cgi-bin/DEGACC/index.cgi?e

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 210
Experimental result iT (mg/l) 210
Exposure duration iT (hours) 96
Robust Study Summary iT
79469-AT-LC50-F-Pimpro.doc
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 762.171
Toxicity to fish (LC50 in mg/l) as predicted by Aster 1,510.73475
Toxicity to fish (LC50 in mg/l) as predicted by PNN 334.0702
Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1 514.6
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 442.489
Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g 23.629
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 7.62E+002

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Intermediate Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment

AgencyAssessment
NTP Carcinogenicity - Reasonably anticipated to be a human carcinogen
IARC Carcinogenicity - Group 2B
EC Carcinogenicity - Category 2

Underlying data regarding Complex Hazard Assessment