Substance Identity
CAS Number 1912-24-9
Chemical Name 1,3,5-Triazine-2,4-diamine, 6-chloro-N-ethyl-N'-(1-methylethyl)-
Type of substance Organic
SMILES n(c(nc(n1)NC(C)C)NCC)c1Cl
Moiety of concern organic
Categorization Results

Meets Government of Canada Categorization Criteria? Yes
Meets Human Health Categorization Criteria? Yes
Meets Environmental Criteria for Categorization? Yes
Persistent (P)? Yes
Rational for P QSAR
Bioaccumulative (B)? No
Rational for B Experiment
Inherently Toxic to Aquatic Organisms (iT)? Yes
Rational for iT Experiment
DSL Quantity range (tonnes/year) >1T to 1000T
Basis for Environment Categorization (PiT, BiT, PBiT) if categorized? PiT

Ecological data supporting decisions

Underlying data regarding persistence

Media of concern leading to Categorization Water
Experimental Biodegradation half-life (days) Not Available
Predicted Ultimate degradation half-life (days) 60
MITI probability of biodegradation 0
TOPKAT probability of biodegradation 0.009
EPI Predicted Ozone reaction half-life (days) 999
EPI Predicted Atmospheric Oxidation half-life (days) 0.3911

Underlying data regarding Bioaccumulation

Empirical Log Kow 2.61
Reference (Log Kow) HANSCH,C & LEO,AJ (1985)
Log Kow predicted by KowWin 2.82
Log BAF T2MTL predicted by Gobas 0.605749707578598
Log BCF 5% T2LTL predicted by Gobas 0.596915600437585
Log BCF Max predicted by OASIS 2.24941994878977
Log BCF predicted by BCFWIN 0.99
Experimental BCF (log) 0.97
Reason for pivotal value Highest Vertebrate BCF
Test species BCF/BAF (Latin) Coregonus fera
Test species BCF/BAF (Common) Whitefish
Mean water concentration (ug/l) 50
Mean water concentration (comment) Below water solubility by a factor of 5
Water concentration: Measured/Nominal/Uncertain Measured
RadioLabel Yes, parent, analyzed by GC
Exposure duration (days) 1
Exposure duration (comment) Sufficient exposure duration for 80% steady state
Exposure type Static
Mean temperature (deg. Celcius) 16
Exposure route Water
Exposure media Fresh Water
Tissue analysed Whole body
Calculation method Cb/Cw
Reference (BAF/BCF) Gunkel, G., and B. Streit. 1980. Mechanisms of Bioaccumulation of a Herbicide (Atrazine, S-Triazine) in a Freshwater Mollusc (Ancylus fluviatilis Mull.) and a Fish (Coregonus fera). Water Res. 14(11):1573-1584

Underlying data regarding inherent toxicity to aquatic organisms

Pivotal value for iT (mg/l) 0.011
Experimental result iT (mg/l) 0.011
Test species iT (Latin) Scenedesmus acutus
Test species iT (Common) Green algae
Final EndPoint iT EC50
Exposure duration iT (hours) 72
Reference iT Toxicol.Environ.Chem. 59:89-99
Robust Study Summary iT
1912249-AT-EC50-O-sceacu.doc
1912249-AT-EC50-O-scesub.doc
Toxicity to fish (LC50 in mg/l) as predicted by Ecosar v0.99g 27.103
Toxicity to fish (LC50 in mg/l) as predicted by Oasis Forecast M v1.10 22.7028
Toxicity to fish (LC50 in mg/l) as predicted by Aster 68.974891
Toxicity to fish (LC50 in mg/l) as predicted by PNN 21.24816
Toxicity to daphnia (EC50 in mg/l) as predicted by Topkat v6.1 12.9
Toxicity to fish, daphnia, algae or mysid shrimp (EC50 or LC50 in mg/l) as predicted by Ecosar v0.99g 30.734
Chronic toxicity to daphnia or algae (EC50 in mg/l) as predicted by Ecosar v0.99g 2.256
Toxicity to fish (LC50 in mg/l) as predicted by Neutral Organics QSAR in Ecosar v0.99g 9.03E+000

Human Health data supporting decisions
Underlying data regarding potential for exposure

LPE/IPE/GPE Lowest Potential for Exposure (HC Simple Exposure Tool)

Underlying data regarding Previous Assessments

Underlying data regarding Simple Hazard Assessment

AgencyAssessment
HC Carcinogenicity - Groups IIIA and IIIB

Underlying data regarding Complex Hazard Assessment